Magnus, Will and Kate travel to Mumbai, India, on their mission to investigation the link to a murder. To make matters worse Will becomes ill before he mysteriously disappears

Dr. Magnus and the team rescue a sinking ship near South Africa. Later at the Sanctuary, one of the passengers of the rescued ship is murdered, with Druitt as the prime suspect. '

Magnus and Will investigate a number of inexplicable teenage disappearances. The common denominator in the case seems to be that they all recently spent time at an exclusive rehab clinic in Mexico. Paying a visit to the clinic, Magnus and Will are surprised to meet the program's director none other than a disguised Nikola Tesla, one of the original Five. Tesla portentously explains he has been working on a treatment that cures the teens of their addictions in merely a week. Magnus and Will know Tesla has an ulterior motive and press him to disclose the real purpose for the clinic. Unable to hold back his excitement, Tesla reveals he is actually turning his patients into Vampires. Tesla's treatment is designed to create a time-release of the Vampire gene, evolving his unsuspecting patients into Vampires over a 30-year period. But when one of his patients discovers the formula to speed up the process, they find themselves up against a powerful and determined group of new Vampires. Unless they can be stopped, Magnus fears Tesla may have unleashed the resurrection of the deadliest race of Abnormals ever to roam the Earth.

Helen reunites with Jimmy who transports an elemental Abnormal to the Sanctuary. However they are tracked down by the underground Mobsters. Kate proves her loyalty and bonds with Jimmy over a common history they share

Magnus and Will try to retrieve a sea creature from the coast of Louisiana, but the Abnormal breaks lose in mid-flight, resulting in a crash landing that imperils the duo

Will goes up against the heads of the Sanctuary Network to defend Magnus who is charged with a shocking murder. But as the evidence stacks up against her, even Will has trouble finding a way to convincingly defend her innocence...